Anti-Wrinkle Injections vs Dermal Fillers: What Is the Difference?

They are often spoken about in the same breath, but they do almost opposite jobs. One relaxes muscle movement, the other restores lost volume.

6 min read · 25 June 2026

Treatment planning for anti-wrinkle injections and dermal fillers with Dr Paul Elgey at UNTIL Marylebone
In this article

The short answer

Anti-wrinkle injections and dermal fillers are the two most common injectable treatments, and they are easy to confuse. The simplest way to keep them apart is this: anti-wrinkle injections relax muscle movement, while fillers replace lost volume.

They solve different problems. One quietens an overactive muscle so a line stops being etched deeper every time you frown. The other rebuilds support where the face has lost structure with age. Used well, and often together, they restore a fresher version of your own face rather than changing it.

How anti-wrinkle injections work

Anti-wrinkle injections use a purified protein, given in tiny medical doses, that temporarily blocks the signal between a nerve and the muscle it controls. The muscle relaxes, so the skin over it creases less, and the lines caused by repeated movement soften. Over three to four months the nerve re-establishes its connection, the muscle resumes normal activity, and a repeat treatment is needed if you want to maintain the effect.

This is why anti-wrinkle injections suit dynamic lines, the ones that appear when you move: forehead lines, frown lines between the brows, and crow’s feet at the eyes. The same medicine also has recognised medical uses, including easing jaw clenching, slimming a bulky jaw muscle, and reducing excessive sweating.

How dermal fillers work

Dermal fillers are gels, most commonly made from hyaluronic acid, a substance the body produces naturally. Placed under the skin, they restore volume and support that has been lost over time, and they can refine contour and proportion.

Filler suits static change, the kind you can see when your face is still: flatter cheeks, a less defined jaw or chin, thinning lips, or shadowed tear troughs. Because hyaluronic acid filler can be dissolved with an enzyme if needed, it is the preferred choice for facial work where reversibility matters.

Which one treats which concern

A useful rule of thumb:

  • Lines that appear only when you move are a muscle issue. Anti-wrinkle injections.
  • Lines, hollows, or flatness present at rest are usually a volume issue. Dermal filler, or a regenerative treatment for skin quality.
  • Skin texture, fine crepiness, and dullness are a skin-quality issue, better suited to skin boosters or polynucleotides than to either of the above.

The reason a consultation matters is that the same visible concern can have more than one cause. Tired-looking eyes, for example, can come from volume loss, skin quality, pigment, or underlying structure, and the right treatment is different in each case.

Why they are often combined

The most natural results frequently use small amounts of both. Relaxing an overactive frown muscle while gently restoring lost cheek support, in one planned approach, addresses both the movement and the structure behind an ageing look. Treating only one when both are involved tends to give a partial result.

The principle here is conservative and whole-face. First-time patients are started on lower doses and reviewed, because a little more can always be added later, whereas an over-treated result has to be waited out. Hyaluronic acid filler is fully dissolvable, so a result that does not feel right can be adjusted.

Bottom line

Anti-wrinkle injections relax muscles and soften lines of movement. Dermal fillers restore lost volume and refine contour. They are not competing options, they are different tools, and the skill is in knowing which your face actually needs, in what amount, and where to stop. Every treatment here is carried out by Dr Elgey, a GMC-registered medical doctor, after a full assessment of the whole face rather than one feature alone.