Polynucleotides
Are you searching for advanced skin rejuvenation treatments?

Regenerative treatment
Polynucleotide Skin Regeneration Treatments in London
Are you searching for advanced skin rejuvenation treatments?
My clinic specialises in the latest innovative polynucleotide treatments in London. Renowned for their exceptional regenerative properties, polynucleotides are the key to achieving youthful and radiant skin.
At my Marylebone clinic, polynucleotides are used to improve:
- Skin hydration and moisture retention
- Elasticity and firmness
- Sun damage and uneven texture
- Redness and reactive, irritated skin
- Crepiness in delicate areas such as the under-eye
Treatments are tailored to your skin's unique needs, so you can expect noticeable improvements in firmness, hydration, and smoothness.
Enhanced Skin Hydration
Increases moisture retention for a plumper, more youthful complexion.
Improved Skin Elasticity
Boosts collagen production, reducing fine lines and wrinkles.
Healing Properties
Helps repair sun damage and improve the overall skin texture.
Anti-inflammatory Effects
Reduces skin redness and irritation, beneficial for sensitive or reactive skin types.
Just had a second polynucleotides treatment under the care of Dr Paul. He took time to explain the treatment, downtime and recovery periods. All of this was done within a friendly engaging environment where he encouraged questions. I'm super happy with the results and the professionalism of how Dr Paul consulted me, especially as I had initially wanted tear trough injections but after review advised on a different course, of polynucleotides. Certainly will be back, and can't recommend enough.
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I had a great experience with Paul for lip filler and Sunekos injections. He is attentive, friendly, and very knowledgeable. He took the time to understand my facial structure, how it moved to ensure a nice balanced and natural look. Also appreciate that he isn’t afraid to say no to more treatments so that things don’t look overdone. Will always be happy to recommend!
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I went to Dr Elgey and had 4 mls of dermal filler which he strategically placed in the temples, cheeks and chin and I am honestly blown away by the results. It’s a real game changer! I went in feeling super nervous but Dr Elgey is so knowledgeable, professional and warm - I quickly felt at ease. We spoke at length about my concerns and then he advised me on where the filler should be placed to get the best results. I had absolutely no bruising afterwards and swelling was minimal. The result is so natural but I look so much younger and fresher. I honestly wish I had done it sooner.
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Paul is fantastic. He uses his experience to understand what you’re looking for and advise on what may work, he does not push or upsell any treatments and he has a real creativity and specialises in achieving a natural result. I trust his knowledge and skills, and his ethics.
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I have had my lip filler done a few times with Paul and they are perfect every time. A natural and full look that I get so many compliments on. Always a lush experience, I highly recommend!
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I have been seeing Dr. Paul for over 3/4 years for a combination of treatments and I couldn’t be happier with the results. His professionalism and meticulous attention to detail are second to none — he truly is a perfectionist in his work. He always takes the time to listen, explain the procedure, and ensure I feel comfortable. I highly recommend Dr. Paul to anyone considering aesthetic treatments — his ability to deliver natural enhancements is truly outstanding.
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I had a consultation and UltraClear treatment with Dr Paul for acne scarring with other skin concerns and my experience has been excellent from start to finish. After speaking with several practitioners, what stood out most was Dr Paul’s honesty and knowledge. I never felt pressured into treatment, and he took the time to explain the reasoning behind his recommendations. Throughout the process, he has been incredibly responsive and supportive, answering all of my questions before and after treatment. He also prepared a personalised pre-treatment skincare cream which made me feel very well looked after. The recovery has also gone smoothly thanks to the clear aftercare instructions and Dr Paul’s ongoing support.
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Highly recommend Paul. He really put me at ease, showed careful consideration and thought for the fact I was coming to him after having previous filler in my lips dissolved due to migration, and kept me very well informed throughout the process. Clearly highly skilled and I am so happy to have found someone I can trust with my lips for the long term!
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The treatment
What are polynucleotides?
Polynucleotides are natural compounds made from nucleotides, the building blocks of DNA and RNA. In aesthetic medicine they use the regenerative properties of these molecules to promote skin rejuvenation, hydration and healing.
Once injected into the skin they attract water molecules to boost hydration, promote collagen production and improve blood flow to the area. This improves skin elasticity and firmness while helping to repair damaged tissue and reduce inflammation, which makes them well suited to ageing skin and to delicate, thin-skinned areas such as the under-eye.

Indications and applications
What Can Polynucleotides Treat?
Polynucleotides are particularly effective for:
Boost skin hydration
Increases moisture retention for a plumper, more youthful complexion.
Improve elasticity and firmness
Boosts collagen production to improve firmness and soften fine lines and wrinkles.
Repair and renew the skin
Helps repair sun damage and improve overall skin texture through natural regeneration.
Calm redness and irritation
Reduces redness and irritation thanks to a documented anti-inflammatory effect, helpful for sensitive or reactive skin.
Refresh the delicate under-eye
Especially suited to thin-skinned areas, where dark circles and crepiness come from skin quality rather than volume loss.
What to expect during and after your session
- Treatment timeAround 30 minutes
- Treatment planA short course of sessions
- Results buildFrom the second session
- Results last6 to 12 months
- SettlesWithin a day or two
- Compatible withProfhilo

Mechanism of action
How Do Polynucleotides Work?
When injected into the skin, polynucleotides stimulate cellular growth and repair.
They attract water molecules, enhancing hydration, promote collagen production, and improve blood flow to the area.
This process not only improves skin elasticity and firmness but also aids in the repair of damaged tissues and reduces inflammation, making it an excellent treatment for ageing skin and various dermatological issues.
What can be treated?
Polynucleotides act as a regenerative agent, hydrating the skin and stimulating new collagen, and are especially suited to delicate, thin-skinned areas such as the under-eye.
- Under-eye dark circles and crepiness
- Reduced skin elasticity and firmness
- Photoageing and pigmentation changes
- Dull or dehydrated skin
- Fine lines and perioral lines
- Redness and skin sensitivity
Treatment areas
Face
Neck
Technique and safety
How your polynucleotide course is delivered
Polynucleotides are purified fragments of DNA that hydrate the tissue, calm inflammation and trigger fibroblasts to lay down new collagen and elastin, which makes them especially suited to delicate areas such as the under-eye.
- Purified, tested fragments of DNA that deliver a consistent, standardised dose
- Bind water to hydrate and stimulate new collagen and elastin
- A documented anti-inflammatory effect on the surrounding tissue
- Planned as a short course of sessions a few weeks apart
- A strong safety profile, being biologically similar to the body's own building blocks

Treatment process
Polynucleotide Treatment Protocol
My approach to polynucleotide treatment includes the following steps:
- Consultation: an initial discussion of your skin concerns and goals to determine the most effective treatment plan.
- Preparation: the target area is thoroughly cleansed and prepared for treatment.
- Injection: using fine needles or a cannula, polynucleotides are carefully injected into the dermal layer of the skin.
- Post-treatment care: avoid make-up or skin products for 4 hours after treatment, and avoid excessive exercise to reduce the risk of swelling and bruising.
Pricing
Polynucleotide Pricing
Pricing depends on:
- The area treated, with the under-eye priced differently to the full face
- The number of sessions in your course
- Any regenerative treatments combined in the same plan
Polynucleotides are a course treatment, not a one-off, so you are quoted for the plan rather than the appointment. That happens at consultation, before anything is booked.

Doctor-led regenerative care
Why Choose Dr Paul Elgey?
Regenerative treatments reward patience and punish overselling. Polynucleotides improve skin quality over months, and the honest conversation is about whether that is what your skin actually needs.
With over 20 years of medical practice and advanced aesthetic training, my focus is:
- Safety
- Precision
- Natural outcomes
- Long-term skin health
I would rather plan a proper course than sell you a single session that will not move the needle.
Book a Consultation
A doctor-led consultation focused on natural, balanced results. Share your goals and concerns and we will guide you through the most appropriate treatment plan.
Polynucleotides FAQs
If you are curious about the treatment, aftercare, or potential side effects, the answers to common questions are below. Polynucleotides work gradually, so knowing what to expect and when matters.
What are Polynucleotides?
Polynucleotides are natural compounds composed of nucleotides, the building blocks of DNA and RNA. In aesthetic medicine, polynucleotide treatments use the regenerative properties of these molecules to promote skin rejuvenation, hydration, and healing. At our London, Dublin and Dubai clinics, we specialise in bespoke polynucleotide treatments designed to enhance skin quality and vitality.
How do Polynucleotides work?
When injected into the skin, polynucleotides stimulate cellular growth and repair by attracting water molecules, enhancing hydration, and promoting collagen production, as well as improve blood flow to the area. This process not only improves skin elasticity and firmness but also aids in the repair of damaged tissues and reduces inflammation, making it an excellent treatment for ageing skin and various dermatological issues.
What is the Polynucleotide treatment protocol?
Our clinic’s approach to polynucleotide treatment includes the following steps: Initial Consultation: We discuss your skin concerns and goals to determine the most effective treatment plan. Preparation: The target area is thoroughly cleansed and prepared for treatment. Injection: Using fine needles or cannula, polynucleotides are carefully injected into the dermal layer of the skin. Post-Treatment Care: Instructions include avoiding make up or skin products for 4 hours post treatment and avoid excessive exercise to reduce risk of swelling and bruising.
What are the benefits of Polynucleotide treatments?
Enhanced Skin Hydration: Increases moisture retention for a plumper, more youthful complexion. Improved Skin Elasticity: Boosts collagen production, reducing fine lines and wrinkles. Healing Properties: Helps repair sun damage and improve the overall skin texture. Anti-inflammatory Effects: Reduces skin redness and irritation, beneficial for sensitive or reactive skin types.
What are the risks of Polynucleotide treatments?
While polynucleotide treatments are generally well-tolerated and safe, they can include minor risks, such as: Mild Swelling and Redness: Typically resolves within a few hours to days. Bruising at Injection Site: Occurs occasionally but is usually temporary. Sensitivity: Some patients may experience temporary sensitivity at the treatment area.
What is the longevity of Polynucleotide treatments?
The results of polynucleotide treatments can last up to 6-12 months and are influenced by factors such as the individual’s skin type, age, and lifestyle. To maintain optimal results, regular treatment sessions as advised during your consultation at our London, Dublin, and Dubai clinics are recommended.
What skin concerns can Polynucleotide treatments help improve?
Polynucleotide treatments are commonly used to support skin quality in patients experiencing a range of age-related and environmental skin concerns. These may include photoaging, where long-term sun exposure contributes to pigmentation changes, fine lines, and reduced skin resilience. They are also used in cases of reduced skin elasticity, which occurs as collagen and elastin levels naturally decline over time, leading to a loss of firmness. Patients with dull or dehydrated skin may benefit, as dehydration and barrier impairment can leave the skin looking tired, rough, or lacking radiance. Fine lines and wrinkles may become more noticeable as collagen production slows and skin structure weakens with age. Polynucleotides are also used to support skin repair and regeneration, helping to improve overall skin resilience and recovery from daily environmental stress. In addition, they may be suitable for certain inflammatory skin conditions, where chronic inflammation contributes to redness, sensitivity, and impaired skin barrier function. Suitability for treatment is always assessed during consultation to ensure the most appropriate approach for each individual.
Written and medically reviewed byDr Paul Elgey, Aesthetic Doctor & GP: MBBS MRCGP · MHRA (Medicines and Healthcare products Regulatory Agency): polynucleotide injectables are CE-marked medical devices.
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Dr Paul Elgey Aesthetics • UNTIL Marylebone, 1 Orchard Street, London W1H 6HJ
BookAppointments typically available within 1–2 weeks



